Should I Add Glutathione To My Diet?

The term glutathione is typically used as a
collective term to refer to the tripeptide
L-gamma-glutamyl-L-cysteinylglycine in both
its reduced and dimeric forms. Monomeric
glutathione is also known as reduced
glutathione and its dimer is also known
as oxidized glutathione, glutathione
disulfide and diglutathione.

In this monograph, reduced glutathione will
be called glutathione -- this is its common
usage by biochemists--and the glutathione
dimer will be referred to as glutathione
disulfide.

Glutathione is widely found in all forms of life
and plays an essential role in the health of
organisms, particularly aerobic organisms.

In animals, including humans, and in plants,
glutathione is the predominant non-protein
thiol and functions as a redox buffer, keeping
with its own SH groups those of proteins in a
reduced condition, among other antioxidant
activities.

Glutathione is present in tissues in concentrations
as high as one millimolar. Cysteine, the business
residue of glutathione, neither has the solubility
nor activity of glutathione at physiological alkaline
pH.

It appears that nature has built the cysteine
molecule into the glutathione tripeptide to
make the amino acid more soluble and allow it
to have redox buffering activity in a living
tissue environment.

Glutathione also plays roles in catalysis,
metabolism, signal transduction, gene expression
and apoptosis. It is a cofactor for glutathione
S-transferases, factors which are involved in
the detoxification of xenobiotics, including
carcinogenic genotoxicants, and for the
glutathione peroxidases, crucial
selenium-containing antioxidant factors.

It is also involved in the regeneration of
ascorbate from its oxidized form,
dehydroascorbate.

There are undoubtedly roles of glutathione that
are still to be discovered.

Glutathione is present in the diet in amounts
usually less than 100 milligrams daily.

Glutathione is not an essential nutrient since
it can be synthesized from the amino acids
L-cysteine, L-glutamate and glycine.

It is synthesized in two ATP-dependent steps:

First, gamma-glutamylcysteine is synthesized
from L-glutamate and cysteine via the factor
gamma-glutamylcysteine synthetase -- the rate
limiting step -- and second, glycine is added
to the C-terminal of gamma-glutamylcysteine
via the factor glutathione synthetase.

The liver is the principal site of glutathione
synthesis. In healthy tissue, more than 90%
of the total glutathione pool is in the reduced
form and less than 10% exists in the disulfide
form.

The glutathione disulfide reductase is the principal
molecule that maintains glutathione in its reduced
form. This latter molecule uses as its cofactor
NADPH (reduced nicotinamide adenine dinucleotide
phosphate). NADPH is generated by the oxidative
reaction in the pentose phosphate pathway.

The consequences of a functional glutathione
deficiency, which results in tissue oxidative
stress, can be seen in some pathological
conditions.

For example, those with glucose 6-phosphate
dehydrogenase deficiency produce lower amounts of
NADPH (Co-factor Q-1) and hence, lower amounts of
reduced glutathione. This condition is
characterized by a hemolytic anemia.

Conditions causing chronic glutathione deficiency
all result in hemolytic anemia, among other
pathological consequences. Oxidative stress caused
by glutathione deficiency results in fragile
erythrocyte (red blood cells) membranes.

Malaria-causing organisms (Plasmodia species)
do not like to feed on these sick erythrocytes.
That is about the only good news regarding this
situation.

Chronic functional glutathione deficiency is also
associated with immune disorders, an increased
incidence of malignancies, and in the case of HIV
dis-ease, probably accelerated pathogenesis of the
dis-ease.

Acute manifestations of functional glutathione
deficiency can be seen in those who have taken
an overdosage of acetaminophen (aspirin). This
results in depletion of glutathione in the
hepatocytes, leading to liver failure and death,
if not promptly treated.

Glutathione is an orphan drug for the treatment
of AIDS-associated cachexia. It is thought that
this disorder is due, in part, to oxidatively-stressed
and damaged enterocytes. There is some evidence that
although orally administered glutathione may not
be absorbed into the blood from the small intestine
to any significant extent, that it may be absorbed
into the enterocytes where it may help repair damaged
cells.

Glutathione in one form or another is the subject
of some medicinal chemistry research and many
clinical trials.

For example, an aerosolized form of glutathione
is being studied in AIDS and cystic fibrosis
patients.

Glutathione, the principal antioxidant of the
deep lung, appears to be diminished in those
with AIDS. Prodrugs of gamma-L-glutamyl-L-cysteine
are being evaluated as anticataract agents.

Glutathione (reduced) is known chemically as
N-(N-L-gamma-glutamyl-L-cysteinyl)glycine and
is abbreviated as GSH. Its molecular formula is
C10H17N3O6S and its molecular weight is 307.33
daltons.

Glutathione disulfide is also known as
L-gamma-glutamyl-L-cysteinyl-glycine disulfide
and is abbreviated as GSSG. Its molecular
formula is C20H32N6O12S2.

Many of the marketed glutathione dietary supplement
products are obtained from yeast fermentation, as is
the orphan drug. This is not the case with Dr.
Robert O. Young's, Young pHorever Glutathione which
is a glutathione extract from avocados.

www.phmiracleliving.com

Glutathione has antioxidant activity. It may
have detoxification, and immunomodulatory
activities, and may have beneficial effects
on sperm motility and in the protection against
noise-induced hearing loss.

Glutathione is the principal intracellular non
protein thiol and plays a major role in the
maintenance of the intracellular redox state.
It may be thought of as an intracellular redox
buffer to help maintain the alkaline design
of the cell.

Glutathione is a nucleophilic scavenger and an
electron donor via the sulfhydryl group of its
business residue, cysteine. Its reducing ability
maintains molecules such as ascorbate and proteins
in their reduced state.

Glutathione is also the cofactor for the
selenium-containing glutathione peroxidases,
which are major antioxidants. These antioxidants
detoxify peroxides, such as hydrogen peroxide
and other peroxides.

Another antioxidant activity of glutathione is
the maintenance of the antioxidant/reducing agent
ascorbate in its reduced state. This is accomplished
via glutathione-dependent dehydroascorbate reductase
which is comprised of glutaredoxin and protein
isomerase reductase. Glutathione may also react
with the reactive nitrogen species peroxynitrite
to form S-nitrosoglutathione.

Glutathione S-transferases (GSTs) consist of a
family of multifunctional factors that metabolize
a wide variety of electrophilic compounds via
glutathione conjunction.

GSTs are involved in the detoxification
of xenobiotic compounds and in the
protection against such degenerative
diseases as cancer.

The mechanism of these factors involves a
nucleophilic attack by glutathione on an
electrophilic substrate. The resulting glutathione
conjugates that form are more soluble than the
original substrates and thus more easily exported
from the cell.

The release of glutathione-S-conjugates
from cells is an ATP-dependent process mediated by
membrane glycoproteins belonging to the
multidrug-resistance protein (MRP) family.

Proteins of the MRP family are essential for the
transport of glutathione S-conjugates into the
extracellular space. They are also known as
glutathionine-S-conjugate pumps.

Absorption of orally administered glutathione has
been observed in some animals (mice, rats,
guinea pigs).

Oral glutathione has been demonstrated to reverse
age-associated decline in immune responsiveness
in mice.

In one study, glutathione was found to
enhance T-cell mediated responsiveness,
including delayed-type hypersensitivity
(DTH). The mechanism of this effect was
ascribed to the antioxidant activity of
glutathione.

Parenterally administered glutathione was
found to improve sperm motility in a small
human trial.

Again, the effect was thought to be due to the
antioxidant activity of this substance.

Noise-induced hearing loss is thought to be due
to oxidative stress. Intraperitoneal administration
of glutathione to guinea pigs was found to protect
against noise-induced hearing loss and once more,
the antioxidant activity of glutathione was thought
to account for this effect.

The pharmacokinetics of oral glutathionine in humans
are not well understood. It appears that in some
animals (mice, rats, guinea pigs), serum glutathione
levels do increase following its oral administration.

Though glutathione is undoubtedly a potent antioxidant.
There is preliminary evidence that it might eventually
prove to be useful in the management of some
cancers, atherosclerosis, diabetes, lung disorders,
noise-induced hearing loss, male infertility
and to help prevent or ameliorate various
toxicities.

It may also have some anti-viral (acid) activity.
Glutathione is an orphan drug for the treatment of
AIDS-associated cachexia.

RESEARCH SUMMARY

The use of glutathione in cancer treatment has
been two-fold. It has been investigated as an
antitumor agent in its own right and as a
chemoprotectant used to diminish the toxicities
of some cancer drugs.

In one animal study, glutathione produced
significant regression of aflatoxin-induced liver
cancers and significantly enhanced survival.

All rats exposed to aflatoxin but not given
glutathione died within 24 months of exposure to
the carcinogen, but 81% of the glutathione-treated
animals were still alive at the end of the 24
months. The researchers concluded that the
glutathione-effect noted in this study "strongly
suggests that this antioxidant merits further
investigation as a potential antitumor agent
in humans."

Human cancer studies, so far, have utilized
glutathione in a secondary role--principally to
protect against the toxicity of cisplatin.
Its role in this regard has been found effective
in several studies wherein it has been demonstrated
to diminish cisplatin-induced nephrotoxicity and
neurotoxicity.

Early research indicates that exogenous glutathione
may significantly inhibit platelet aggregation and
improve other hemostatic and hemorheological factors
in atherosclerotic patients. In other preliminary
clinical work, glutathione has been found to help
preserve renal function in patients who had coronary
artery bypass operations.

A glutathione nasal preparations has been helpful
in reversing the oxidant-antioxidant imbalance in
idiopathic pulmonary fibrosis, and it has helped
suppress lung epithelial surface inflammatory
cell-derived oxidants in patients with cystic fibrosis.

Similar nebulizing treatment has been given to HIV
patients to augment deficient glutathione levels
of the lower respiratory tract with the idea of
improving host defense in these immuno-compromised
individuals.

Glutathione has also been shown to enhance insulin
secretion in elderly subjects with impaired glucose
tolerance. There are some further preliminary
indications that glutathione might be helpful in
some with diabetes, but more research is needed
before any meaningful conclusions can be made.

In a double-blind, placebo-controlled study,
injected glutathione demonstrated a significant
positive effects on sperm motility and morphology
in infertile men. And, finally, in another study
that needs followup, glutathione exhibited
significant in vitro inhibition of herpes simplex
virus type 1 replication. It appears that the
mechanism of this effect is due to glutathione's
redox-modulating active. Some viral (acidic)
outfections, including HIV outfection, result
in oxidative stress which may be a major mechanism
of their pathogenesis, modulating oxidative stress
could be an antiviral (antiacid) maneuver.

Glutathione is an orphan drug for the treatment of
AIDS-associated cachexia.

Oral doses of up to 2000 milligrams daily are well
tolerated. There are no reports of adverse
reactions.

INTERACTIONS DRUGS

Cisplatin (Chemothearpy drug): Glutathione,
administered parenterally, may ameliorate some
of the adverse reactions of cisplatin.

OVERDOSAGE

There have been no reports of glutathione overdosage
in the literature.

DOSAGE AND ADMINISTRATION

Glutathione is available as a single ingredient
dietary supplement. Dosage ranges from 50 to
2000 milligrams daily. One teaspoon pr Young
pHorever Liquid Glutathione equals 430 milligrams.

www.phmiracleliving.com

HOW SUPPLIED

Liquid - one teaspoon of Young pHorever
Glutathione equals 430 milligrams.

To learn more about Young pHorever
Liquid Glutathione or to order go to:

www.phmiracleliving.com

SHOULD I ADD LIQUID GLUTATHIONE TO MY DIET?

Yes, as a major protectant from
dietary and lifestyle acidity.

LITERATURE

Anderson ME, Luo JL. Glutathione therapy:
from prodrugs to genes. Semin Liver Dis.
1998; 18:415-424.

Aw TW, Wierzbicka G, Jones DP. Oral glutathione
increases tissue glutathione in vivo.
Chem Biol Interact. 1991; 80:89-97.

Bains JS, Shaw CA. Neurodegenerative
disorders in humans: the role of glutathione
in oxidative stress-mediated neuronal death.
Brain Res Brain Res Rev. 1997; 25:335-358.

Borok Z, Buhl R, Grimes GJ, et al. Effect
of glutathione aerosol on oxidant-antioxidant
imbalance in ideopathic pulmonary fibrosis.
Lancet. 1991; 338:215-216.

Broquist HP. Buthionine sulfoximine, an
experimental tool to induce glutathionine
deficiency: elucidation of glutathionine
and ascorbate in their role as antioxidants.
Nutr Rev. 1992; 50:110-111.

Brown LA, Bai C, Jones DP. Glutathione
protection in aveolar type II cells from
fetal and neonatal rabbits. Am J Physiol.
1992; 262:L305-L312.

Cascinu S, Cordella L, Del Ferro E, et al.
Neuroprotective effect of reduced
glutathione on cisplatin-based chemotherapy
in advanced gastric cancer: a randomized
double-blind placebo-controlled study.
J Clin Oncol. 1995; 13:26-32.

Cheung P-Y, Wang W, Schulz R. Glutathione
protects against ischemia-perfusion injury
by detoxifying peroxynitrite. J Mol Cell
Cardiol. 2000; 32:1669-1678.

De Mattia G, Bravi MC, Laurenti O, et al.
Influence of reduced glutathione infusion
on glucose metabolism in patients with
non-insulin-dependent diabetes mellitus.
Metabolism. 1998; 47:993-997.

Exner R, Wessner B, Manhart N, Roth E.
Therapeutic potential of glutathione.
Wien Klin Wochenschr. 2000; 112:610-616.

Favilli F, Marraccini P, Iantomasi T,
Vincenzini MT. Effect of orally administered
glutathione levels in osme organs of rats:
role of specific transporters. Br J Nutr.
1997; 78:293-300.

Flagg EW, Coates RJ, Eley JW, et al. Dietary
glutathione intake in humans and the
relationship between intake and plasma
total glutathionine level. Nutr Canc.
1994; 21:33-46.

Furukawa T, Meydani SN, Blumberg JB. Reversal
of age-associated decline in immune
responsiveness by dietary glutathione
supplementation in mice. Mech Ageing
Dev. 1987; 38:107-117.

Griffith OW. Biologic and pharmacologic
regulation of mammalian glutathione
synthesis. Free Rad Biol Med. 1999;
27:922-935.

Hagen TM, Jones DP. Transepithelial transport
of glutathione in vascularly perfused small
intestine of rat. Am J Physiol. 1987;
252(5 Pt 1):G607-G613.

Hagen TM, Wierzbicka GT, Sillau AH, et al.
Bioavailability of dietary glutathione:
effect on plasma concentration.
Am J Physiol. 1990; 259(4 Pt 1):G524-G529.

Hayes JD, McLellan LI. Glutathione and
glutathione-dependent enzymes represent
a co-ordinately regulated defence against
oxidative stress. Free Rad Res. 1999;
31:273-300.

Hayes JD, Strange RC. Glutathione S-transferase
polymorphisms and their biological consequences.
Pharmacology. 2000; 61:154-166.

Hercbergs A, Brok-Simoni F, Holtzman F, et al.
Erythrocyte glutathione and tumor response to
chemotherapy. Lancet. 1992; 339:1074-1076.

Holroyd KJ, Buhl R, Borok Z, et al. Correction
of glutathione deficiency in the lower
respiratory tract of HIV seropositive
individuals by glutathione aerosol treatment.
Thorax. 1993; 48:985-989.

Hwang C, Sinskey AJ, Lodish HF. Oxidized
redox state of glutathione in the endoplasmic
reticulum. Science. 1992; 257:1496-1502.

Janaky R, Ogita K, Pasqualotta BA, et al.
Glutathione and signal transduction in the
mammalian CNS. J Neurochem. 1999; 73:889-902.

Lash LH, Hagen TM, Jones DP. Exogenous
glutathione protects intestinal epithelial
cells from oxidative injury. Proc Natl
Acad Sci USA. 1986; 83:4641-4645.

Lenzi A, Culasso F, Gandini L, et al.
Placebo-controlled, double-blind,
cross-over trial of glutathione therapy
in male infertility. Hum Reprod. 1993;
8:1657-1662.

Lenzi A, Picardo M, Gandini L, et al.
Glutathione treatment of dyspermia:
effect on the lipoperoxidation process.
Hum Reprod. 1994; 9:2044-2050.

Loguercio C, Di Pierro M. The role of
glutathione in the gastrointestinal
tract: a review. Ital J Gastroenterol
Hepatol. 1999; 31:401-407.

Lyons J, Rauh-Pfeiffer A, Yu YM, et al.
Blood glutathione synthesis rates in
healthy adults receiving a sulfur amino
acid-free diet. Proc Natl Acad Sci USA.
2000; 97:5071-5076.

Martensson J, Jain A, Meister A. Glutathione
is required for intestinal function.
Proc Natl Acad Sci USA. 1990; 87:1715-1719.

Meister A. On the antioxidant effects of
ascorbic acid and glutathionine. Biochem
Pharmacol. 1992; 44:1905-1915.

Murphy ME, Scholich H, Sies H. Protection
by glutathione and other thiol compounds
against the loss of protein thiols and
tocopherol homologs during microsomal
lipid peroxidation. Eur J Biochem. 1992;
210:139-146.

Nagasawa HT, Cohen JF, Holleschau AM,
Rathbun WB. Augmentation of human and
rat lenticular glutathione in vitro by
prodrugs of gamma-L-glutamyl-L-cysteine.
J Med Chem. 1996; 39:1676-1681.

Novi AM. Regression of aflatoxin B1-induced
hepatocellular carcinomas by reduced
glutathione. Science. 1981; 212:541-542.

Ohinataab Y, Yamasobac T, Schachta J,
Millera JM. Glutathione limits noise-induced
hearing loss. Hear Res. 2000; 146:28-34.

Palamara AT, Perno C-F, Ciriolo MR, et al.
Evidence for antiviral activity of glutathione:
in vitro inhibition of herpes simplex virus type
1 replication. Antiviral Res. 1995; 27:237-253.

Paolisso G, Giugliano D, Pizza G, et al.
Glutathione infusion potentiates glucose-induced
insulin secretion in aged patients with
impaired glucose tolerance. Diabetes Care.
1992; 15:1-7.

Roum JH, Borok Z, McElvaney NG, et al.
Glutathione aerosol suppresses lung
epithelial surface inflammatory cell-derived
oxidants in cystic fibrosis. J Appl Physiol.
1999; 87:438-443.

Samiec PS, Drews-Botsch C, Flagg EW, et al.
Glutathione in human plasma: decline in
association with aging, age-related macular
degeneration, and diabetes. Free Radic Biol
Med. 1998; 24:699-704.

Schmidinger M, Budinsky AC, Wenzel C, et al.
Glutathione in the prevention of cisplatin
induced toxicities. A prospectively randomized
pilot trial in patients with head and neck
cancer and non small cell lung cancer. Wien
Klin Wochenschr. 2000; 112:617-623.

Shaw CA, ed. Glutathione in the Nervous
System. London: Taylor and Francis; 1998.

Sies H. Glutathione and its role in cellular
functions. Free Rad Biol Med. 1999;
27:916-921.

Smyth JF, Bowman A, Perren T, et al.
Glutathione reduces the toxicity and
improves quality of life of women diagnosed
with ovarian cancer treated with cisplatin:
results of a double-blind, randomized trial.
Ann Oncol. 1997; 8:569-573.

Sternberg P Jr, Davidson PC, Jones DP, et al.
Protection of retinal pigment epithelium from
oxidative injury by glutathione and precursors.
Invest Opthalmol Vis Sci. 1993; 34:3661-3668.

Witschi A, Reddy S, Stofer B, Lauterburg BH.
The systemic availability of oral glutathione.
Eur J Clin Pharmacol. 1992; 43:667-669.

Copyright © 2007 by Robert O. Young, Ph.D.

www.articlesofhealth.blogspot.com

Continue lendo

Dozens of Studies on Pomegranate's Strong Antioxidant and Anti-Inflammatory Properties

Dozens of recent studies reveal the pomegranate's
surprising array of benefits. Pomegranates contain
powerful antioxidants that appear to inhibit the
onset of atherosclerosis, reduce the risk of heart
disease, and mediate high blood pressure.

Pomegranate extract also has demonstrated
anticarcinogenic properties that are effective in
suppressing a variety of cancers, including skin,
breast, and colon cancers. The pomegranate has
even shown effectiveness in alleviating depression
in a mouse model of menopause.

The pomegranate (Punica granatum) is a hardy,
long-lived subtropical shrub originating in
semi-arid regions of Asia.1,2,3

It has been cultivated and naturalized over
the whole of the Mediter-ranean region since
ancient times. Pomegranates are mentioned in
Egyptian papyrus scrolls dating back to 1550 BC,
and pomegranate branches form part of the
decorative motif on the pillars of King
Solomon's temple.

Spanish settlers introduced pomegranates to
California in 1769.2 In the US today, they are
typically cultivated in the drier parts of
California and Arizona.

Buffering Free Radicals or Hydrogen Ions

Free radicals--the oxygen-reactive byproducts of
normal cellular metabolism that attack healthy
cells--have been implicated in the acceleration
of the body's natural aging processes. Free
radicals can also be formed by external
environmental factors such as cigarette smoke
and other forms of air pollution.4

Damage by unchecked free-radical compounds can
manifest as serious illnesses; for example, cancer
is now known to be associated with free-radical
damage to healthy cellular DNA.

More than a decade ago, pomegranate peel extracts
were shown to possess significant antioxidant
activity in various in-vitro models.4

An extract of pomegranate peel was fed to rats,
which were then exposed to carbon tetrachloride,
a toxic chemical. The pretreatment with pomegranate
extract protected levels of the antioxidant enzymes
catalase, peroxidase, and superoxide dismutase in
the rats. The pomegranate extract also helped to
protect the rats' livers from the toxic effects
of carbon tetrachloride.5

Another more recent study focused on the
antioxidant effectiveness of plant pigments
called bioflavonoids, commonly found in berries,
cherries, grapes, and citrus. Pomegranate juice
was found to exhibit three times more antioxidant
activity than red wine or green tea.6 The active
constituent that appears to be responsible is
ellagic acid, a naturally occurring polyphenolic
compound in pomegranates.

Unclogging Arteries

Numerous studies of atherosclerosis suggest that
the disease is at least partly caused by
free-radical reactions involving diet-derived
lipids that induce harmful changes in the
arterial walls.7

A recent study by the Lipid Research Laboratory
in Haifa, Israel, explored dietary supplementation
with polyphenolic antioxidants in animals. The
researchers noted that pomegranate juice was
associated with the inhibition of low-density
lipoprotein (LDL) oxidation and with slowing
the development of atherosclerosis.8

The Israeli researchers further ascertained the effects
of pomegranate juice consumption by atherosclerotic
patients with carotid artery stenosis (a narrowing
of the carotid artery walls). Ten patients
supplemented with the juice for one year.

In the pomegranate-supplemented group, carotid
intima-media thickness, an indicator of
atherosclerosis progression, was reduced by up to
30%. By contrast, in a control group that did not
consume pomegranate juice, carotid intima-media
thickness increased by 9% over 12 months. Moreover,
in the pomegranate-supplemented patients, serum LDL
levels were also significantly reduced while serum
total antioxidant status increased by 130% after
one year.9

Reducing Hypertension

Hypertension (high blood pressure) affects an
estimated 50 million Americans and augments the
risk for stroke, heart disease, peripheral
vascular disease, and kidney disease.

Pomegranates may be of benefit in modulating this
often silent yet potentially lethal risk factor
for heart disease.

In the Israeli study, systolic blood pressure was
reduced by 21% after one year of pomegranate juice
consumption.10 This effect is believed to be related
to the particularly potent antioxidant properties
of pomegranate polyphenols.

A similar study at the same research facility
examined consumption of pomegranate juice to
ascertain its effectiveness in lowering blood
pressure.

Researchers studied the effect on hypertensive
patients of daily consumption of 50 ml of
pomegranate juice. After two weeks, a 5% reduction in
systolic blood pressure was noted, along with a
36% decrease in serum angiotensin converting enzyme
(ACE) activity.11

Reduc-tion in serum ACE activity has previously
been shown to attenuate atherosclerosis, independent
of its effects on blood pressure. The study authors
concluded, "Pomegranate juice can offer wide protection
against cardiovascular diseases, which could be related
to its inhibitory effect on oxidative stress and on
serum ACE activity."

Improving Lipid Profiles

A recent Iranian study examined the effects of
concentrated pomegranate juice on lipid profiles of
type II diabetes patients with elevated blood lipids,
or hyperlipidemia. The patients supplemented with
pomegranate juice for eight weeks. The study
participants saw significant reductions in their
total cholesterol, LDL, LDL:HDL (high-density
lipoprotein) ratio, and total cholesterol:HDL ratio.
Serum HDL and triglycerides did not change
significantly.

The study authors concluded that consumption of
concentrated pomegranate extract may modify
heart-disease risk factors in patients with high
cholesterol.12

Further research is needed to determine whether
pomegranate helps lower blood lipid levels in
non-diabetic individuals.

Anti-Tumor-Promoting Effects

In recent years, chemoprevention has received as much
attention as chemotherapy in the fight against cancer.
The search for new ways to stop cancer before its onset
has led investigators to examine a wide variety of
natural agents.

A recent study at the University of Wisconsin argues
that agents capable of intervening at more than one
critical pathway in the process of carcinogenesis
"will have greater advantage over other
single-target agents."13

The Wisconsin researchers found that pomegranate
fruit extract possesses strong antioxidant
and anti-inflammatory properties.

The extract was evaluated for anti-tumor-promoting
effects, specifically involving topical application
against skin tumors. The researchers concluded that
animals pretreated with pomegranate fruit extract
showed 70% less tumor incidence compared to animals
that did not receive it. The study authors believe
that their results provide "clear evidence that
possesses anti-skin-tumor-promoting effects," and
may possess chemopreventive activity "in a wide range
of tumor models."14

These findings support the promising results of a pair
of 2003 studies in South Dakota and Japan that
explored pomegranate seed oil as a safe and effective
agent against skin cancer and colon cancer tumors,
respectively.15,16

In a 2002 study, pomegranate seed oil (CLA) inhibited
the proliferation of human breast cancer cells up to
90%, while fermented pomegranate juice polyphenols
inhibited 47% of cancerous lesion formation in mammary
gland cells from mice.15 Ellagic acid, a polyphenol
derived from pomegranate, has been identified to have
potent antioxidant, anti-cancer, and
anti-atherosclerotic properties.17

No Known Toxicity

A variety of recent studies have demonstrated that
pomegranate, in various forms, can be included as
part of a healthy lifestyle with no risk of toxic
reactions. A Cuban study, for example, found that
two doses of pomegranate extract (0.4 and 1.2 mg per
kilogram of body weight, respectively) given to rats
produced no toxic effects in terms of food intake,
weight gain, or behavioral or biochemical factors.17

Another study took these results further, examining
still higher doses of pomegranate extract administered
orally to rats for 37 days.18 No significant differences
in toxicity were found in the treated rats in any of the
blood parameters analyzed, a finding corroborated by
analyses of both the liver and kidney.

Adding the benefits of pomegranate to the diet has
presented something of a challenge. The fruit itself
is messy and rather difficult to prepare due to its
large number of seeds. Prepackaged pomegranate juice,
either pure or in concentrate, remains relatively
scarce in Western supermarkets and health food stores
and most of it is loaded with added sugars.

Encapsulated or powdered forms of pomegranate extract
and oils (CLA) are becoming much more widely available,
making it easier to control the daily dosage.

http://www.phmiracleliving.com/phruits.htm
www.articlesofhealth.blogspot.com

Conclusion

The pomegranate, an ancient alkalizing fruit
whose regenerative properties have been celebrated
for thousands of years, has come under growing scrutiny
by medical researchers seeking natural agents for
the prevention and treatment of degenerative diseases.

In numerous recent experiments, pomegranates have been
shown to contain powerful antioxidant compounds that
scientists believe may inhibit atherosclerosis, cut the
risk of heart disease, and help to modulate high blood pressure.

Pomegranate seed oil (CLA) also has
demonstrated anticarcinogenic properties
that appear to suppress skin, breast, colon,
and other cancers.

These varied and very promising disease-promoting
effects are likely to make the pomegranate the focus
of modern medical research for some time to come.

For more information on pomegranate or pomegranate
seed oil (CLA) or to order Young pHorever
Pomegranate Seed Oil (CLA) go to:

http://www.phmiracleliving.com/phruits.htm or
www.articlesofhealth.blogspot.com

References

1. New Larousse Encyclopedia of Mythology.
London: Hamly; 1983.

2. Brown D. Encyclopedia of Herbs and Their Uses.
London: Dorling Kindersley; 1995.

3. Morton J. Fruits of warm climates.
Creative Resource Systems, Inc.; 1987:352-5.

4. Butterfield HM. A history of subtropical fruits
and nuts in California. University of California,
Agricultural Experiment Station. 1963.

5. Langseth L. Oxidants, antioxidants and disease
prevention. International Life Science Institute,
Belgium; 1996.

6. Chidambara Murthy KN, Jayaprakasha GK, Singh RP.
Studies on antioxidant activity of pomegranate
(Punica granatum) peel extract using in vivo models.
J Agric Food Chem. 2002 Aug 14;50(17):4791-5.

7. Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft
DM, Kader AA. Antioxidant activitiy of pomegranate
juice and its relationship with phenolic composition
and processing. J Agric Food Chem. 2000 Oct;48(10):
4581-9.

8. Harman D. Role of free radicals in aging and
disease. Ann NY Acad Sci. 1992 Dec 26; 673:126-41.

9. Aviram M, Rosenblat M, Gaitini D, et al.
Pomegranate juice consumption for 3 years by
patients with carotid artery stenosis reduces
common carotid intima-media thickness, blood
pressure and LDL oxidation. Clin Nutr. 2004
Jun;23(3):423-33.

10. Aviram M, Dornfeld L. Pomegranate juice
consumption inhibits serum angiotensin converting
enzyme activity and reduces systolic blood
pressure. Atherosclerosis. 2001
Sep;158(1):195-8.

11. Esmaillzadeh A, Tahbaz F, Gaieni I,
Alavi- Majd H, Azadbakht L. Concentrated
pomegranate juice improves lipid profiles in
diabetic patients with hyperlipi- demia. J Med Food.
2004 Fall;7(3):305-8.

12. Afaq F, Saleem M, Krueger CG, Reed JD,
Mukhtar H. Anthocyanin-and hydrolyzable
tannin-rich pomegranate fruit extract modulates
MAPK and NF-kappaB path- ways and inhibits skin
tumorigenesis in CD-1 mice. Int J Cancer. 2004
Sep 28.

13. Hora JJ, Maydew ER, Lansky EP, Dwivedi C.
Chemopreventive effects of pomegranate seed oil
on skin tumor development in CD1 mice. J Med Food.
2003 Fall;6(3):157- 61.

14. Kohno H, Suzuki R, Yasui Y, Hosokawa M,
Miyashita K, Tanaka T. Pomegranate seed oil
rich in conjugated linolenic acid suppresses
chemically induced colon carcinogenesis in
rats. Cancer Sci. 2004 Jun;95(6):481-6.

15. Kim ND, Mehta R, Yu W, et al. Chemopreventive
and adjuvant therapeutic potential of pomegranate
(Punica granatum) for human breast cancer. Breast
Cancer Res Treat. 2002 Feb;71(3):203-17.

16. Seeram NP, Lee R, Heber D. Bioavailability of
ellagic acid in human plasma after consumption of
ellagitannins from pomegranate (Punica granatum L.)
juice. Clin Chim Acta. 2004 Oct;348(1- 2):63-8.

17. Vidal A, Fallarero A, Pena BR, Medina ME et al.
Studies on the toxicity of Punica granatum L.
(Punicaceae) whole fruit extracts. J Ethnopharmacol.
2003 Dec;89(2-3):295-300.

18. Cerda B, Ceron JJ, Tomas-Barberan FA, Espin JC.
Repeated oral administration of high doses of the
pomegranate ellagitannin punicalagin to rats for 37
days is not toxic. J Agric Food Chem. 2003 May.

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Almond Rule Making Some Farmers and Consumers Go Nuts

The day will soon come when we will haveto become farmers in order to provide the alive food we need to sustain life.

Pasteurizing or gasing almonds or any food or drink destroys the zeta potential or life forceof that food or drink.

Yesterday, Garance Burke wrote a disturbingarticle, released by the Associated Press,on what is about to happen to oneof America's most important foods - the almond!

The beginning to the end to raw unpasteruizedfood has already begun.

Many of you might remember the study on cats whenthey fed the first generation raw food, the secondgeneration pasteurized food and the third generationirradiated foods.

There were birth defects by the third generation andthe fourth generation could not even reproduce themselves.

The point is, we are headed down the same road unlesswe stop this madness!

We need to educate our leaders NOW and make them awareof this REAL problem!

Please read the follow article and let your local leaders know how you feel about what is happeningto OUR food supply.

Kindest regards,

Dr. Robert O. Young

phmiraclesecrets@aol.comwww.phmiraclesecretswww.articlesofhealth.blogspot.com

Almond Rule Making Some Farmers Go Nuts
Wednesday, June 27, 2007
6:24 AM ED
The Associated Press
By GARANCE BURKE
Associated Press Writer


MADERA, Calif. (AP) -- Raw, organic almonds form the basis of Karyn Calabrese's garlicky nut pate, her vegan pie crusts and vanilla ice cream custards.

But under a new federal rule requiring that virtually all almonds be pasteurized to prevent foodborne illness, the Chicago restaurateur will have to substitute a new nut, or go to vast lengths to import her raw almonds from across the globe.

Industry representatives say tightening food safety rules to subject almonds to heat treatment will help expand the market for California farmers, who grow about 80 percent of the world's almonds in a flat strip of land sandwiched between the Pacific coast and the Sierra Nevada mountains.

But the regulation, set to take effect Sept. 1, has also angered everyone from organic farmers to followers of the restrictive raw foods diet.

"The almond is the king of the nut world and a main staple for raw foodists," said Calabrese, whose elegant restaurants feature small plates of raw, vegan food, none of which has been heated above 110 degrees. "I haven't even thought out what I'll do because it's just such a mind-blowing situation."

Almonds have become increasingly lucrative as they've gained popularity with health-conscious consumers. California farmers expect to harvest 1.3 billion pounds of almonds this year, a bumper crop worth more than $1.4 billion.

Following Salmonella outbreaks in 2001 and 2004 that were traced to raw almonds, the Almond Board of California rallied for a federal rule requiring all almonds in the state to be pasteurized to keep bacteria from infecting the nuts while they dry in the orchard or while they're processed.

"We consider it unacceptable to continue shipping a product that could contain a microorganism that could make somebody sick," said Richard Waycott, President and CEO of the board, a marketing arm of the U.S. Department of Agriculture. "We're really confident that this program is a win-win for everybody because it does not alter the product."

In pasteurization -- a process also used for milk, juice and eggs -- the shelled and hulled nuts typically are laid out on a conveyor belt that passes them through a moist burst of steam to heat the kernels' surface to about 200 degrees, killing any pathogens present. An alternative process sends the nuts into a chamber where they're sprayed with propylene oxide gas.

Major almond buyers such as Mars Inc., Kraft Foods Inc. and The Hershey Co. reviewed a study by the board to determine if the process impacted the nut's quality, taste, texture and appearance, and found it had no effect, Waycott said.

Once treated, the pasteurized almonds are ready for sale and can be legally shipped throughout the U.S., Canada and Mexico, said Michael Durando, chief for the marketing order administration branch at USDA.

Growers can apply for exemptions if they can prove that their manufacturing process -- be it dry roasting, blanching or any other traditional treatments -- achieves pasteurization. They also can sell small quantities of raw, unpasteurized almonds direct to customers at farm stands or at certified California farmers markets, but can face penalties if they're caught selling more than 100 pounds a day to any one person.

That's not enough volume for Berkeley-based Living Tree Community Foods, which soon will start importing its raw almonds from Spain to make its "living" nut butter. Company officials said its customers are concerned about the health effects of propylene oxide, a gas listed as a possible carcinogen by the International Agency on Cancer Research.

Federal guidelines found that extremely low residue levels of the gas had no harmful effects, Waycott said. But the Cornucopia Institute, a Wisconsin-based farm policy research group, asked the USDA to hold off on implementing the rule to solicit an independent study on the chemical.

The rule was developed over three years of careful discussions between industry representatives and agriculture officials, and won't be reconsidered, Durando said.

Madera-based farmer Mike Braga, whose organic nuts are favored by live food fans and grocery chains such as Trader Joe's, said he won't break the law by continuing to sell raw almonds. But if customers aren't demanding it, he said he doesn't see why he shouldn't be able to freeze his almonds instead of pasteurizing them.

"We're going to lose our entire raw market," Braga said. "If such good almonds are available here, why should our customers have to import them from Europe?"

For more information go to:

www.phmiracleliving.com or
www.articlesofhealth.blogspot.com

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Pomegranate Reduces Intestinal Inflammation, Enriches Blood, Cleans Arteries and Protects Against Cancer

Pomegranates are nearly round, 2-1/2 to 5 in. wide fruit crowned at the base by the prominent calyx.

The tough, leathery skin or rind is typically yellow overlaid with light or deep pink or rich red.

The interior is separated by membranous walls and white, spongy, bitter tissue into compartments packed with sacs filled with sweetly acid, juicy, red, pink or whitish pulp or aril.

In each sac there is one angular, soft or hard seed full of Omega 5 oils (CLA).

The arils (seed casings) of the pomegranate are consumed raw. The entire seed is eaten, though the fleshy outer portion of the seed is the part that is desired. The taste differs depending on the variety of pomegranate and its state of ripeness.

Pomegranate juice is a popular drink in the Middle East, and is also used in Iranian and Indian cuisine; it began to be widely marketed in the U.S. in 2004.

Pomegranate concentrate is used in Syrian cuisine. Grenadine syrup is thickened and sweetened pomegranate juice; it is used in cocktail mixing. Before the tomato arrived to the Middle East, grenadine was widely used in many Persian foods; it can still be found in traditional recipes. The juice can also be used as an antiseptic when applied to cuts. In addition, Pomegranate seeds are sometimes used as a spice and theseeds are the best source of Omega 5 or CLA oils.

The primary commercial growing regions of the world are the Near East, India and surrounding countries and southern Europe. In California commercial cultivation is centered in the southern San Joaquin Valley.

One pomegranate delivers 40% of an adult's daily vitamin C requirement. It is also a rich source of folic acid and of antioxidants.

Recent research into the health benefits of Pomegranates has created unprecedented demand both in the United States and Europe.

Recent studies have been published showing a positive relationships between pomegranate consumption and prostate cancer, carotid arteries and hypertension.

The pomegranate and its color have been the object of great fascination, particularly in Oriental cultures. The Arabs were great admirers and promoters of its cultivation, making it the symbol of the Moslem Kingdom of Granada in the southern Iberian Peninsula.

The scarlet blossoms of the pomegranate appear as dazzling flames against the dark green backdrop of the tree's leaves. The tiny beads of fruit, full of precious oil and juice, are brilliant as drops of blood or rubies. These drops of blood from the pomegranate when consumed will help to build healthy red blood cells, according to the ancients who wrote the "Law of Similars".

King Solomon compared the cheeks of his beloved to the pomegranate three thousand years ago.

Here at the Rancho del Sol, in sunny ValleyCenter, California, the home of the pH Miracle Center, we are happy to say that we also grow pomegranates, along side our avocados and grapefruits for very special and important life saving reasons.

The pomegranate is quite rich in vitamins C, E, and B6, containing, as well, significant amounts of B1, B2, and niacin. The most abundant minerals are potassium for alkalizing, copper for purification, and iron for building hemoglobin.

Among its non-nutritive components the following are worth noting:

Tannins, in small amounts. These are much more prevalent in the rind of the fruit or in the membrane that separate the seed sacs. These tannins have an astringent and anti-inflammatory effect on the mucosa of the digestive tract.

Anthocyanins are reddish or bluish vegetable pigments belonging to the flavonoid group act as antiseptics and anti-inflammatory substances in the digestive tract and as potent antioxidants within the body cells, halting the aging process and cancerous acidic degeneration.

Pelletierine is an alkaloid and is effective vermifuge (expulses intestinal parasites) that is found primarily in the bark of the roots of the tree. The rind and the membranes also contain this alkaloid, but not the seed sacs.

Together, thee components give the pomegranate the following properties: astringent, anti-inflammatory, vermifuge, remineralizer, alkalinizer, antioxidant, and depurant.

The pomegranate is suitable in cases of outfectious diarrhea caused by excess acidity leading to gastroenteritis or colitis because of its astringent and anti-inflammatory action on the digestive tract. It is also beneficial in cases of flatulence or intestinal cramps. Surprising results have been achieved in chronic cases such as ulcerative colitis or granulomatous colitis (Chrohn's dis-ease).

Intestinal parasites, tenia or tapeworm, in particular are eliminated by eating the inner walls of the pomegranate.

Because of its astringent action it reduces the production of hydrochloric acid and thus reduces inflammation in an irritated stomach.

The pomegranate contains a significant amount of copper at 70 ug/100g., a trace element that helps to purify the blood as well as helps in the absorption of iron in building red blood cells.

Because of its rich content of flavonoids and antioxidant, which halt the processes of arterial aging, the pomegranate seed oil is recommended in cases of reduced arterial blood flow. It is very beneficial in heart attack prevention and cardiac health in general.

To order Young pHorever CLA pomegranate oil go to:

www.phmiracleliving.com or call at:

760-751-8321.

Because pomegranates are rich in potassium, they are appropriate for those suffering from hypertension. They help avoid excessive numbers of both systolic and diastolic pressure.
Pomegranates are of value in cases of gout, excess uric acid, and acid causing obesity because of its alkalizing and depurant effect.

Pomegranates are loaded with Omega 5 CLA oils which have been found to neutralize acids associated with arteriosclerosis, breast cancer, prostate cancer and especially obesity.

Dr. Robert O. Young is suggesting to ingest at least 3000mgs to 4000mgs of pomegranate Omega 5 CLA oil per day for helping the body maintain its alkaline design and buffer the acids that make us sick, tired and fat.

You can order your Young pHorever CLA Omega 5 pomegranate oil on-line at:

www.phmiracleliving.com or call at:

760 751-8321.

Copyright © 2007 by Robert O. Young, Ph.D.

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Organic & Natural Skin, Hair & Body Care by the Young's

We see natural skin care education as a key to our strength and viability as a sensitive skin, hair and body care product company.

We believe consumers should be informed to enable them to make the best choices about organic skin care.

We have discovered that knowing what NOT to put on your face, body and hair is as important and perhaps more important than what you do.

Since there is so much confusion in the market place, we have made a list of the most dangerous and damaging ingredients commonly used in the face, body and hair care industry.

Some of these ingredients you can not pronounce unless you are a chemist and many of these are listed on products using a different name, but we will continue to update this list to keep you informed of these damaging, allergenic, and many times carcinogenic pollutants to your body and the environment. Some of these ingredients are more dangerous then others, but we believe NONE of these ingredients should be applied to your face, hair or body under any circumstances and you should avoid them at all cost.

Young pHorever Skin, Hair and Body Care – A Revolutionary Skin, Hair and Body care You Can Trust

http://www.phmiracleliving.com/young-pHorever.htm

1. Imidazolidinyl Urea and Diazolidinyl Urea - These are the most commonly used preservatives after the parabens. They are well established as a primary cause of contact dermatitis (American Academy of Dermatology). These ingredients are derived from ANIMAL urine.

2. Methyl, Propyl, Butyl, and Ethyl Paraben - These are preservatives, or commonly known used as inhibitors of microbial growth, which extends the shelf life of products. Parabens are widely used even though they are known to be toxic. Parabens have been known to cause many allergic reactions and skin rashes. Methyl paraben combines benzoic acid with the methyl group of chemicals and is highly toxic.

3. Petrolatum - Petrolatum is mineral oil jelly, and mineral oil causes a lot of problems when used on the skin-it can produce photosensitivity (i.e., promotes sun damage), and it tends to interfere with the body's own natural moisturizing mechanism, leading to dry skin and chapping, hence creating what the product is intended to prevent.

4. Propylene Glycol - Propylene Glycol is a vegetable glycerin mixed with grain alcohol, which are both "natural". Usually it is a synthetic petrochemical mix used as a humectant. Proplylene glycol been known to cause allergic and toxic reactions and alcohols are drying to the skin and toxic.

5. PVP/VA Copolymer - A petroleum-derived chemical used in hairsprays, wave sets and other cosmetics. It can be considered toxic, since particles may contribute to foreign bodies in the lungs of sensitive persons.

6. Sodium Lauryl Sulfate - This synthetic substance is used in shampoos for its detergent and foam-building abilities. It causes eye irritations, skin rashes, hair loss, scalp scurf similar to dandruff, and allergic reactions. It is frequently disguised in pseudo-natural cosmetics with the parenthetic explanation "comes from coconut". SLS is a detergent that poses serious health threats. Used in garage floor cleaners and engine degreasers. Research indicates that exposure to SLS can result in eye damage, depression, labored breathing, diarrhea, severe skin irritation, and even death! Eyes may not develop properly if exposed to SLS. SLS can be transformed into nitrosamines, a potent class of carcinogens. Your body can retain SLS for up to five days and maintain residual levels in the heart, liver, lungs, and brain.

7. Stearalkonium Chloride - A chemical used in hair conditioners and creams, which causes allergic reactions because it is highly toxic. Stearalkonium chloride was developed by the fabric industry as a fabric softener, and is a lot cheaper and easier to use in hair conditioning formulas than proteins or herbals, which do help hair health.

8. Synthetic Colors - The synthetic colors used to supposedly make a cosmetic "pretty" should be avoided at all costs, along with hair dyes. They will be labeled as FD&C or D&C, followed by a color and a number. Example: FD&C Red No. 6 / D&C Green No. 6. Synthetic colors are believed to be cancer-causing agents. If a cosmetic has them in it, don't use the cosmetic. FD&C Yellow 5, Red 40, Blue #1 are synthetic colors from coal tar that deposits toxins onto the skin, causing skin irritation. Absorption can cause depletion of oxygen in the body and death.

9. Synthetic Fragrances - The synthetic fragrances used in cosmetics can have as many as 200 ingredients. There is no way to know what the chemicals are, since on the label it will simply say "Fragrance". Some of the problems caused by these chemicals are headaches, dizziness, rash, hyper-pigmentation, violent coughing, vomiting, skin irritation, and the list goes on. Advice: Don't buy a cosmetic that has the word "Fragrance" on the ingredients label.

10. Triethanolamine (TEA) - Often used in cosmetics to adjust the pH, and used with many fatty acids to convert acid to salt (stearate), which then becomes the base for a cleanser. TEA causes allergic reactions including eye problems, dryness of hair and skin, and could be toxic if absorbed into the body over a long period of time.

11. Saccharomyces Magnesium Ferment - an acid from a yeast which causes damage to the insulin producing beta cells and pancreatic cancer.

12. Butylene Glycol - an acid that may be narcotic and cause asphyxiation.

13. Aqua Biomin Saccharomyces/Magnesium Ferment - This is a yeast and an acid that causes diabetes and other topical yeast infections that can lead to a host of serious symptoms.

14. DMDM Hydantoin - releases a powerful acid and neuro toxin formaldehyde which causes joint pain, skin reactions, allergies, depression, headaches, chest pains, ear infections, chronic fatigue, dizziness, and loss of sleep. Exposure also irritates the respiratory system, triggers heart palpitations or asthma, and aggravates coughs. Other side effects are a weakened immune system and cancer.

15. Cocomidopropyl Hydroxysultaine - has added chemicals in the processing of the coconut oil which are carcinogenic.

16. Tea lauryl sulfate - is hormone disrupting chemical that can form cancer-causing nitrates. This ingredient is restricted in Europe due to the carcinogenic effects. Repeated applications can result in liver and kidney cancer.

17. Lactic Acid - This is a cancer causing agent. An acid found around all cancerous tumours.

18. Alcohol - Alcohol is a free radical and can cause dryness and flaking of the skin. Also very drying and are known to cause allergeric reactions and skin irritation.

19. Hydroquinone - This ingredient is commonly used in skin whitening products. It is also commonly used in plastics manufacturing and is a highly toxic chemical. This ingredient should not be used on humans or animals. Hydroquinone is a well known carcinogen and is known as a liver, blood, lung and respiratory, reproductive organ and skin toxicant.

20. Ethyl Acetate - This is a highly toxic chemical and is used in cosmetics. This is also used in paint remover products, including nail polish remover. Do not put this ingredient on your body, especially your face.

For more information on Young pHorever Skin, Hair and Body Care Products go to:

http://www.phmiracleliving.com/young-pHorever.htm

Copyright © 2007 by Robert O. Young, Ph.D.

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Scientific Studies on the Health Benefits of Pomegranate

The mythical pomegranate has been a scientific enigma since biblical times. Recent interest in the therapeutic properties of the pomegranate has resulted in a number of independent clinical studies from scientists around the world that have begun to substantiate the pomegranate's legendary powers. I have included links to some of these independently published studies.

Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12002340&dopt=Abstract

Nam Deuk Kim, Rajendra Mehta, Weiping Yu, Ishak Neeman, Talia Livney, Akiva Amichay, Donald Poirier, Paul Nicholls, Andrew Kirby, Wenguo Jiang, Robert Mansel, Cheppail Ramachandran, Thangaiyan Rabi, Boris Kaplan and Ephraim Lansky Department of Pharmacy, Pusan National University, Pusan, Korea; Department of Surgical Oncology, College of Medicine, University of Illinois, Chicago, IL; School of Biological Sciences, University of Texas at Austin, Austin, TX; Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel; Rimonest Ltd., Science Park Technion, Nesher, Israel; Laboratory of Molecular Endocrinology, Laval University Medical Research Center, Quebec, Canada; Welsh School of Pharmacy, Redwood Building, Cardiff University; Metastasis Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, UK; Research Institute, Miami Children's Hospital, Miami, FL, USA; Department of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv; Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petach Tikva, IsraelBreast Cancer Research and Treatment 71: 203-217, 2002.

Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells.

http://www.liebertonline.com/doi/abs/10.1089/jmf.2004.7.274#search=%22Pomegranate%20extracts%20potently%20suppress%20proliferation%2C%20xenograft%20growth%2C%20and%20invasion%20of%20human%20prostate%20cancer%20cells.%22

Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman I, Geldof AA, Campbell MJ.Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany.J Med Food. 2004 Fall;7(3):274-83.

Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across matrigel

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15744587&dopt=Abstract

Ephraim Philip Lansky, Gregory Harrison, Paul Froom and Wen G. JiangRimonest Ltd., P.O.B. 9945, Haifa, Israel; Metastasis and Angiogenesis Research Group, University of Wales, College of Medicine, Cardiff, UK; Department of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelInvestigational New Drugs 23: 121-122, 2005.

Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions

http://www.springerlink.com/content/kkt75w5k2081832p

Ephraim P. Lansky, Wenguo Jiang, Huanbiao Mo, Lou Bravo, Paul Froom, Weiping Yu, Neil M. Harris, Ishak Neeman and Moray J. Campbell Rimonest Ltd, Horev Center, Box 9945, Haifa, Israel; University Department of Surgery, University of Wales College of Medicine, Cardiff, UK; Department of Nutrition and Food Science, Texas Women's University, Denton, TX, USA; Department of Epidemiology and Preventive Medicine, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; School of Biological Sciences, University of Texas at Austin, Austin, TX, USA; Department of Urology, Royal Bournemouth Hospital, Bournemouth, UK; Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel; Division of Medical Sciences, University of Birmingham Medical School, Birmingham, UKInvestigational New Drugs 23: 11-20, 2005

Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD Mice

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16221534&dopt=Abstract

Justin J. Hora, Emily R. Maydew, Ephraim P. Lansky, and Chandradhar DwivediDepartment of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, USA; and Rimonest Ltd., Horev Center, Haifa, IsraelJournal of Medicinal Food, J Med Food 6 (3) 2003, 157-161.

Pomegranate as a cosmeceutical source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16221534&dopt=Abstract

Aslam MN, Lansky EP, Varani J.Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road/Box 0602, Ann Arbor, MI 48109, USA.J Ethnopharmacol. 2006 Feb 20;103(3):311-8. Epub 2005 Oct 10.

Dietary effect of a pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF Rats

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=534798

Keisuke Arao, Yu-Ming Wang, Nao Inoue, Junichi Hirata, Jae-Young Cha, Koji Nagao and Teruyoshi YanagitaDepartment of Applied Biological Sciences, Saga University, Saga 840-8502, JapanLipids in Health and Disease 2004, 3:24.

Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14732284&dopt=Abstract

Danny A. van Elswijk, Uwe P. Schobel, Ephraim Lansky, Hubertus Irth, Jan van der GreefKiadis, Niels Bohrweg 11-13, 2333 AC, Leiden, The Netherlan; Rimonest Ltd., Science Park Technion, Nesher, Israel; Department of Analytical Chemistry and Applied Spectroscopy, Vrije Universiteit, Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands; Leiden-Amsterdam Center for Drug Research, Division of Analytical Chemistry, University of Leiden, PO Box 9502, 2300 RA, Leiden, The Netherlands.Phytochemistry 65 (2004) 233-241

Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14739618&dopt=Abstract

Masakazu Toi, Hiroko Bando, Cheppail Ramachandran, Steven J. Melnick, Atsushi Imai, Rose S. Fife, Raymond Eric Carr, Tsutomu Oikawa & Ephraim Philip LanskyDepartment of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Research Institute, Miami Children's Hospital, Miami, FL, USA; Department of Obstetrics and Gynecology, Gifu University, School of Medicine, Tsukasamachi, Gifu, Japan; Department of Medicine, Indiana University of Medicine, Indianapolis, Indiana, USA; Department of Molecular Oncology, The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan; Rimonest Ltd., Horev Center, Haifa, Israel.Angiogenesis 6: 121-128, 2003.

Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavanoids

http://www.rimonest.com/research11.html

Shay Yehoshua Schubert, Ephraim Philip Lansky, Ishak NeemanLaboratories of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa32000, Israel; Rimoni Corporation, Science Park, Nesher, IsraelJournal of Ethnopharmacology 66 (1999) 11-17..

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Pomegranate Juice Consumption for 3 Years by Patients with Carotid Artery Stenosis Reduces Common Carotid Intima-Media Thickness, and Blood Pressure

This randomized controlled pilot study of 19 patients (ages 65-75) is the first to show that pomegranate juice may reduce the amount of plaque in the arteries of patients with heavy plaque buildup (severe carotid artery stenosis) as well as substantially benefiting several important blood parameters.

Ten patients consumed 8 oz. a day of pomegranate juice for 1 year. Nine patients who did not consume pomegranate juice served as controls. The intima-media thickness (IMT) of the carotid artery wall was measured and blood samples were taken at the beginning of the study and at 3, 6, 9 and 12 months.

After 1 year, those patients who did not consume pomegranate juice showed a 9% increase in IMT, while those consuming juice showed a decrease in IMT of up to 30%. Furthermore, for those drinking pomegranate juice, systolic (but not diastolic) blood pressure was reduced by 21%, total antioxidant status of the blood increased by 130%, LDL oxidation decreased by 90%, antibodies to oxidized LDL decreased by 19% and serum paraoxonase 1 (PON1) increased by 83%.

Major blood biochemical markers were not affected, including levels of LDL and HDL cholesterol.

Benefits were maintained in five patients who continued drinking pomegranate juice for 2 additional years, with further improvements in serum lipid peroxidation.

Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld, Volkova N, Presser D, Attias J, Liker H, Hayek T. Clinical Nutrition (2004), 23: 423-433.

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Menopause: Midlife Discomfort Can Be Minimized With Mineral Salts & Pomegranate Seed Oil (CLA)

Around the age of 35, a woman's reproductive organs are affected by dietary and metabolic acids and become less active.

This results in a decrease of the acid estrogen (which isa good thing)but a build up of other dietary and metabolic acids resulting in irregular menstrual cycles and frequent side effects such as water retention, weight gain and mood swings (which is a bad thing).

Eventually, around the ages of 45 to 54, all menstrual bleeding stops resulting in a condition known as menopause, which affects 50 million women in the U.S.

During menopause, estrogen, an acidic waste product of reproductive activity drops off dramatically. This does not mean you need more of the acidic hormone estrogen - what you need is less dietary and metabolic acids and improved elimination of these acids.

A deficiency in alkalinity and especially themineral salts, including sodium chloride, sodium bicarbonate and potassium bicarbonate, can result in osteoporosis, loss of skin elasticity (wrinkles), elevated cholesterol levels, high blood pressure, hot flashes, mood swings and even depression.

That's why I recommend Alkaline Replacement Therapy (ART)to correct the over-acidic condition and warn women of the toxic acidic affects from Estrogen Replacement Therapy (ERT) and its many symptomologies, including cancer.

It is known that alkalinity increases the bones' ability to absorb calcium, reducing the risk of weak bones and osteoporosis. Alkalizing mineral salts also lowers your risk of heart disease and stroke, which is certainly no small matter, considering that heart disease is the leading kilter of women over age 45.

Many studies show that estrogen supplements can increase the risk of breast and uterine cancer.

Why?

Because estrogen is an acidic waste product of glandular function.

Taking the acidic hormone estrogen would be like pumping carbon monoxide into your gas tank. Just as carbon monoxide is an acidic waste product of energy production so estrogen is an acidic waste product of a woman's reproduction function and is toxic to the body.

This is making some doctors more conservative about dispensing prescriptions for estrogen, particularly to women who have a family history of reproductive - system cancer.
Many of these high-risk women are successfully using phyoestrogens, herbs and other nutrients instead of estrogen to treat their menopausal symptoms.

Why?

Because the phytoextrogens are buffers of the this acidic hormone, called estrogen.
Even women who are not at high risk for reproductive-system cancers find that alkalizing herbs, mineral salts and seed oils offer a positive solution to their menopausal woes.

And for many women who do take the acid estrogen, the herbs, alkaline mineral salts and seed oils will allow them to take a lower dose of estrogen or even get off of these toxic acidic waste products!

The Fabulous Phytoestrogens

Plant estrogens (called "phytoestrogens") are alkaline substances in plants that buffer and neutralize the human estrogen acid and protects the female reproductive organs.

In fact, phytoestrogens have been present in the human diet for thousands of years and is an alkaline source to buffer dietary and metabolic acids, including estrogen, especially in midlife and beyond.

Photoestrogens activity is also known to be found in pomegranate seed oil (CLA).
Recently, researchers have discovered that the pomegranate seed oil (CLA) is one of the richest sources of estrone.

Animal-based estromes are often used to treat symptoms of menopause, but many women are reluctant to use these substances.

The pomegranate seed oil estrone buffers the acidic affects of estrogens and reduces the negative health symptoms associated with menopause.

Dr. Robert O. Young has found in his research that alkaline buffers from mineral salts and seedoils can be very helpful in maintaining the alkaline design of a woman's body, especiallysupporting a healthy and active reproductive system.

He recommends an increase in alkaline mineral salts of sodium bicarbonate and potassium bicarbonate with a new product he calls, pHour Salts.

For more information on these alkaline mineral salts go to:

http://www.phmiracleliving.com/pHourSalts.htm

He also recommends 3 to 4 grams of pomegranate seed oil (CLA) to help support the female reproductive system and prevent the symptoms associated with female reproductive acidic stress.

For more information on Young pHorever Pomegranate Seed Oil(CLA) go to:

www.phmiracleliving.com or call at: 760-751-8321

Copyright © 2007 by Robert O. Young, Ph.D.

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Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD1 Mice

1: J Med Food. 2003 Fall;6(3):157-61.

Hora JJ, Maydew ER, Lansky EP, Dwiveda C. Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, U.S.A.

Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice.

In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD(1) mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly promotion using 12-O-tetradecanoylphorbol 13-acetate (TPA).

The experimental group was pretreated with 5% pomegranate seed oil prior to each TPA application. Tumor incidence, the number of mice containing at least one tumor, was 100% and 93%, and multiplicity, the average number of tumors per mouse, was 20.8 and 16.3 per mouse after 20 weeks of promotion in the control and pomegranate seed oil-treated groups, respectively (P <.05).

In a second experiment, two groups each consisting of three CD(1) mice were used to assess the effect of pomegranate seed oil on TPA-stimulated ornithine decarboxylase (ODC) activity, an important event in skin cancer promotion. Each group received a single topical application of TPA, with the experimental group receiving a topical treatment 1 h prior with 5% pomegranate seed oil.

The mice were killed 5 h later, and ODC activity was assessed by radiometric method. The experimental group showed a 17% reduction in ODC activity.

Pomegrante seed oil (5%) significantly decreased (P <.05) tumor incidence, multiplicity, and TPA-induced ODC activity. Overall, the results highlight the potential of pomegranate seed oil as a safe and effective chemopreventive agent against skin cancer.

PMID: 14585180 [PubMed - indexed for MEDLINE]

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Pomegranates May Clear Clogged Arteries

A new study shows that pomegranate juice may help fight hardening of the arteries.

Researchers found that pomegranate juice not only appears to prevent hardening of the arteries by reducing blood vessel damage, but the antioxidant-rich juice may also reverse the progression of this disease.

Hardening of the arteries, known medically as atherosclerosis, refers to the build up of plaque in the walls of arteries. This causes decreased blood flow that can lead to heart attacks and strokes.

Pomegranate Juice Soothes Stressed Arteries

In the study, researchers tested the effects of pomegranate juice on samples of human cells that line blood vessels. The cells were exposed to excessive physical stress, such as might occur with high blood pressure.

Cells that were treated with pomegranate juice had less evidence of damage from the stress.

In addition, tests on mice showed that pomegranate juice significantly slowed hardening of the arteries that developed from high cholesterol. If further studies show those results in humans, researchers say pomegranate juice may be useful in both prevention and treatment of heart disease.

Pomegranate Tops Other Juices

The tests showed that pomegranate juice reduced the effects of stress on human blood vessel cells by stimulating the production of nitric oxide. This chemical is thought to help keep arteries open and keep blood flowing.

Researchers say the beneficial effects of pomegranate juice on hardening of the arteries are likely largely due to its high antioxidant content. The study showed that the antioxidant level in pomegranate juice was higher than that found in other fruit juices, including blueberry, cranberry, orange, and even red wine.

Previous studies on red wine, black tea, and purple grape juice have already indicated these antioxidant-rich beverages can protect arteries from damage by improving blood flow.

However, large clinical trials using different antioxidants have yet to show that antioxidants can prevent heart attacks and other major heart-related events.

The results of this study appear in the current issue of the Proceedings of the National Academy of Sciences.

SOURCES:

Nigris, F. Proceedings of the National Academy of Sciences, March 21, 2005 early online edition; vol 102: pp 4896-4901.

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Pomegranates Suppress Prostate Cancerous Cells

A new study by researchers at the University of California at Los Angeles found that drinking pomegranate juice can fight prostate cancer.

The study included 48 men with recurrent prostate cancer, half of which drank eight ounces of pomegranate juice a day and half of which drank no pomegranate juice. The juice drinkers went 37 months before recurrence, whereas the group that did not drink the juice went just 15 months.

Related articles on this topic are also available on the NewsTarget Network, including: Colloidal silver gaining ground as a proven, effective antibiotic remedy.

Overview:

Drinking 8 ounces of pomegranate juice daily can suppress prostate cancer activity in men with recurrent prostate cancer, according to a study presented Monday at the annual meeting of the American Urological Association in San Antonio.

The study included the cases of 48 men with recurrent prostate cancer. The study was conducted by Dr. Allan J. Pantuck and collegues from the University of California at Los Angeles.

The study found that men with recurrent prostate cancer who drank no pomegranate juice got the doubling time of 15 months for prostate specific antigen (PSA) while those who drank 8 ounces a day got 37 months of PSA doubling time. PSA is an indicator for the tumor activity.

The results indicated that pomegranate juice suppresses the cancer activity. It is believed that antioxidants in pomegranate juice have anti-cancer properties. Phytochemicals such as phytoestrogens may also attribute to these benefits.

No serious side effects were found with the use of pomegranate juice.

Researchers plan to do phase III randomized trials now that the results of the study showed that pomegranate juice is promising.

Previous studies in lab mice by other researchers found that drinking pomegranate juice may help reduce the risk of heart disease. Pomegranate juice can not only relax the oxidative stress on human coronary artery endothelial cells, but reduce the plague build-up in mice by 30 percent.

Source:

http://www.foodconsumer.org/777/8/Pomegranate_juice_helps_fight_prostate_cancer.shtml

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Pomegranates Show Promise for Reversing Prostate Cancer

The juice of the pomegranate, say researchers at the Uinversity of Wisconsin Medical School shows major promise to combat prostate cancer - the most common invasive cancer and the second-leading cause of cancer death in American men.

With more than 230,000 new cases of prostate cancer expected to be diagnosed this year alone in the U.S. and the outlook poor for patients with metastatic disease, researchers are looking for new strategies to combat the disease. Earlier research at Wisconsin and elsewhere has shown that the pomegranate, a fruit native to the Middle East, is rich in anti-oxidant and anti-inflammatory activity and is effective against tumors in mouse skin. In fact, pomegranate juice has higher anti-oxidant activity than do red wine and green tea, both of which appear promising as anti-cancer agents.

The UW research team aimed to find out if the extract from pomegranates would not only kill existing cancer, but help prevent cancer from starting or progressing. Using human prostate cancer cells, the team first evaluated the fruit extract's effect, at various doses, on those cells cultured in laboratory dishes. They found a "dose-dependent" effect - in other words, the higher the dose of pomegranate extract the cells received, the more cells died.

The research team then progressed to tests in mice that had been injected with prostate cancer cells from humans and developed malignancies. The 24 mice were randomly divided into three groups. The control group received normal drinking water, while the animals in the second and third groups had their drinking water supplemented with .1 percent and .2 percent pomegranate extract respectively. The doses for the mice were chosen to parallel how much pomegranate juice a typical healthy human might be willing to eat or drink daily.

The results were dramatic: the mice receiving the higher concentration of pomegranate extract showed significant slowing of their cancer progression and a decrease in the levels of prostate-specific antigen (PSA), a marker used to indicate the presence of prostate cancer in humans.

The animals that received only water had tumors that grew much faster than those in the animals treated with pomegranate extract.

"Our study - while early - adds to growing evidence that pomegranates contain very powerful agents against cancer, particularly prostate cancer," says lead author Hasan Mukhtar, professor of dermatology in the UW Medical School. "There is good reason now to test this fruit in humans - both for cancer prevention and for treatment."

The next step in the evaluation of pomegranates for cancer prevention and treatment is to conduct tests in humans, according to Mukhtar.

The other members of the research team are Arshi Malik, Farrukh Afaq, Vaquar Adhami, Deeba Syed and Sami Sarfaraz, all research scientists in the department of dermatology.

The Wisconsin research was funded by the National Institutes of Health.

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Pomegranates May Thwart Osteoarthritis, Prostate Cancer and Hardening of the Arteries

Researchers aren't making that declaration just yet. But they have found signs that natural compounds called antioxidants in pomegranates may thwart osteoarthritis.

Osteoarthritis is the most common type of arthritis, with more than 20 million patients in the U.S., according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

The pomegranate study was done at Case Western Reserve University.

The researchers included Tariq Haqqi, PhD, a professor of medicine.

The results appear in The Journal of Nutrition.

Pomegranate Project Pomegranate extract was pitted against osteoarthritis in lab tests. That's not the same as tests on people or animals, but it's a first step. Pomegranate extract did two things in those lab tests. It cut levels of an inflammatory chemical called interleukin-1b (IL-1b).

It also curbed enzymes that erode cartilage. Cartilage is a hard but slippery coating on the end of each bone that helps bones slide smoothly past each other.

Osteoarthritis develops when cartilage is broken down; exposed bone breaks down, causing pain, inflammation, and disability.

First Findings

This is the first study to show pomegranate's potential against osteoarthritis, note the researchers.

The results "indicate the pomegranate fruit extract or compounds derived from it may inhibit cartilage degradation in osteoarthritis and may also be a useful nutritive supplement for maintaining joint integrity and function," they write.

Researcher's Comments

"Arthritis is one of the foremost diseases for which patients seek herbal or traditional medicine treatments," says Haqqi in a news release. "However, all the extracts and herbs have not been scientifically evaluated for their efficacy and safety. Indeed, some of them may even interfere with current treatments," he continues. "Therefore, careful use of supplements and herbal medicines during early stages of disease or treatment may be made to limit the disease progression," says Haqqi.

As always, discuss any supplement use with your doctor.

Pomegranate Potion

The researchers didn't just crack open a pomegranate and put it in a blender. They also didn't use juice from the supermarket.

Instead, they made their own pomegranate extract from powdered pomegranate. Sophisticated filtering and measuring was used for science's sake. The pomegranate has "been revered through the ages for its medicinal uses," write the researchers. Antioxidants in pomegranates fight inflammation and may also counter cancer and heart disease.

In May, researchers reported that pomegranate juice may help prevent the return of prostate cancer.

In March, another study showed that pomegranate juice may fight hardening of the arteries.

Pomegranate Season Pomegranates are in season in the U.S. in the fall. They've got a thick, red, leathery skin. The seeds inside are the edible part.

Want to try a pomegranate?

You might want to wear a bib or old clothes. The seeds leave a very strong stain and are used as a dye.

Sources: Ahmed, S. The Journal of Nutrition, September 2005; vol 135: pp 2096-2102. National Institute of Arthritis and Musculoskeletal Diseases, "Handout on Health: Osteoarthritis." News release, Case Western Reserve University. WebMD Medical News: "Pomegranate Juice May Curb Prostate Cancer." WebMD Medical News: "Pomegranate Juice May Clear Clogged Arteries." U.S. Department of Agriculture.

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Chemopreventive and Adjuvant Therapeutic Potential of Pomegranate for Human Breast Cancer

Breast Cancer Res Treat. 2002 Feb;71(3):203-17.

Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Portier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachandran C, Rabi T, Kaplan B, Lansky E Department of Pharmacy, Pusan National University, Korea.

Fresh organically grown pomegranates (Punica granatum L.) of the Wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical CO2-extracted seed oil.

Exposure to additional solvents yielded polyphenol-rich fractions ('polyphenols') from each of the three components. Their actions, and of the crude whole oil and crude fermented and unfermented juice concentrate, were assessed in vitro for possible chemopreventive or adjuvant therapeutic potential in human breast cancer.

The ability to effect a blockade of endogenous active estrogen biosynthesis was shown by polyphenols from fermented juice, pericarp, and oil, which inhibited aromatase activity by 60-80%.

Fermented juice and pericarp polyphenols, and whole seed oil, inhibited 17-beta-hydroxysteroid dehydrogenase Type 1 from 34 to 79%, at concentrations ranging from 100 to 1,000 microg/ml according to seed oil >> fermented juice polyphenols > pericarp polyphenols.

In a yeast estrogen screen (YES) lyophilized fresh pomegranate juice effected a 55% inhibition of the estrogenic activity of 17-beta-estradiol; whereas the lyophilized juice by itself displayed only minimal estrogenic action. Inhibition of cell lines by fermented juice and pericarp polyphenols was according to estrogen-dependent (MCF-7) >> estrogen-independent (MB-MDA-231) > normal human breast epithelial cells (MCF-10A).

In both MCF-7 and MB-MDA-231 cells, fermented pomegranate juice polyphenols consistently showed about twice the anti-proliferative effect as fresh pomegranate juice polyphenols.

Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast cancer cells at 50 microg/ml.

In a murine mammary gland organ culture, fermented juice polyphenols effected 47% inhibition of cancerous lesion formation induced by the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of pomegranate in human breast cancer may be warranted.

PMID: 12002340 [PubMed - indexed for MEDLINE]

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Pomegranates Lower The Risk of Alzheimer's

Alzheimer's disease is the leading cause of dementia in people over the age of 65, affecting an estimated 290,000 Canadians in this age category.

It's a progressive, degenerative disease and while the cause is unknown, researchers are investigating a number of different possibilities such as family history, dietary or metabolic acids or elements in the environment.

There are many studies looking at the role of diet in lowering the risk of Alzheimer's. While there's still a lot that we don't know about this dis-ease, there is some research suggesting a role for fruits, vegetables and juices in reducing risk.

A study published in last month's American Journal of Medicine said that drinking fruit or vegetable juice could significantly lower the risk. This was observed when American researchers followed a group of about 1, 800 people over a 10-year period. Those who drank juice three or more time a week were 76% less likely to develop signs of the dis-ease than those who typically had one serving or less every week.

There is some thought that polyphenols, naturally occurring plant chemicals with powerful antioxidant capacity, which are abundant in these foods may provide this protection. These antioxidants have a number of important functions, one being their ability to deactivate harmful free radicals. Some scientists think that there is a link between these free radicals in the body and early changes in the brain cells in people who later develop the disease. When it comes to different fruits and vegetables that may provide protection, new research has looked at components in pomegranates that may also play a role.

A recent animal study suggests that pomegranate juice could lower the build-up of harmful proteins that are linked to Alzheimer's disease. It's probable that this juice alone is not the total answer, but the combination of elements found in a variety of fruits and vegetables may help. If you've never eaten a pomegranate or had a drink of its juice, there are lots of reasons to give this a try.

Open up a pomegranate and you'll find hundreds of tiny red seeds, juicy pulp and a good amount of fibre, vitamin C and more potassium than a medium-sized orange.

Pomegranates and their juice are rich in phytochemicals including anthocyanins and ellagic acid.

Antioxidants

These powerful antioxidants help add pomegranate juice to the growing list of foods that are dis-ease fighters.

There is also some research suggesting that fish rich in omega-3 fatty acids may lower risk. These omega-3 fats are an important part of nerve and brain cells membranes, make up part of the communication network in the brain and are a key component in brain development.

You'll get your omega-3 fats by eating fatty fish such as salmon, mackerel, herring, sardines, trout or from foods such as omega-3 hemp seed and flax seed.

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Pomegrantes

Pomegranates are nearly round, 2-1/2 to 5 in. wide fruit crowned at the base by the prominent calyx.

The tough, leathery skin or rind is typically yellow overlaid with light or deep pink or rich red.

The interior is separated by membranous walls and white, spongy, bitter tissue into compartments packed with sacs filled with sweetly acid, juicy, red, pink or whitish pulp or aril.

In each sac there is one angular, soft or hard seed.

The arils (seed casings) of the pomegranate are consumed raw. The entire seed is eaten, though the fleshy outer portion of the seed is the part that is desired. The taste differs depending on the variety of pomegranate and its state of ripeness.

Pomegranate juice is a popular drink in the Middle East, and is also used in Iranian and Indian cuisine; it began to be widely marketed in the U.S. in 2004. Pomegranate concentrate is used in Syrian cuisine. Grenadine syrup is thickened and sweetened pomegranate juice; it is used in cocktail mixing. Before the tomato arrived to the Middle East, grenadine was widely used in many Persian foods; it can still be found in traditional recipes. The juice can also be used as an antiseptic when applied to cuts. In addition, Pomegranate seeds are sometimes used as a spice.

The primary commercial growing regions of the world are the Near East, India and surrounding countries and southern Europe. In California commercial cultivation is centered in the southern San Joaquin Valley.

One pomegranate delivers 40% of an adult's daily vitamin C requirement. It is also a rich source of folic acid and of antioxidants.

Recent research into the health benefits of Pomegranates has created unprecedented demand both in the United States and Europe. Recent studies have been published showing a positive relationships between pomegranate consumption and prostate cancer, carotid arteries and hypertension.

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Pomegranates Protect Against Atherosclerosis

Researchers have revealed that pomegranates may provide important health benefits for diabetic patients.

According to results published in the August 2006 issue of Atherosclerosis, subjects who drank 180 ml (6 oz.) of pomegranate juice per day for three months experienced a reduced risk for atherosclerosis, a condition that leads to arterial wall thickening and hardening.

The researchers also found that drinking pomegranate juice reduced the uptake of oxidized LDL (“bad” cholesterol) by large, versatile immune cells known as macrophages. Oxidized LDL uptake by macrophages is a main contributing factor to the development of atherosclerosis.

One surprising finding, said lead researcher Professor Michael Aviram of the Technion Faculty of Medicine, was that the sugars contained in pomegranate juice – although similar in content to those found in other fruit juices – did not worsen diabetes disease parameters (including blood sugar levels) in the patients, but in fact reduced the risk for atherosclerosis.

“In most juices, sugars are present in free – and harmful – forms,” explained Aviram. “In pomegranate juice, however, the sugars are attached to unique antioxidants, which actually make these sugars protective against atherosclerosis.”

The findings of this small (20 subjects) study are part of Aviram’s ongoing research into the effects of pomegranates on cholesterol oxidation and cardiovascular diseases. In his previous widely published studies, Aviram was the first to prove that consuming red raspberry reduces cholesterol oxidation and arteriosclerosis, which leads to heart disease, a major cause of morbidity and mortality in the Western world.

His later studies confirmed the antioxidant and anti-atherosclerotic benefits of licorice, olive oil, onions and pomegranates.

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Dr. Young Releases Three New Anti-Aging Pomegranate Products

Dr. Robert O. Young is excited to announce the release of three NEW incredible all natural and all organic, anti-aging and antioxidant synergistic products.

These three NEW products are at the foundation and beginning of a whole new line of anti-aging and anti-oxidant products:

1) Young pHorever CLA(TM)
2) Young pHorever pHruits(TM) in capsule, and
3) Young pHorever pHruits(TM) in powder form.

To begin, let me share with you the incredible benefits of Young pHorever CLA(TM):

Young pHorever CLA(TM) Pomegranate Seed Oil is cold pressed using an extraction process that provides 100% extra virgin, pure pomegranate seed oil with a very high concentration of Punicic oil.

Each capsule contains 1000mg. pomegranate seed oil, a healthy Omega-5 conjugated fatty acid. This is equivalent to the pomegranate seed oil from four and a half whole pomegranates.
It takes about 500 lbs of fresh pomegranates to produce 1 lb of pomegranate seed oil.

Pomegranate seed oil is one of the only plant sources of conjugated fatty acids (CLA).

Punicic oil is a compound closely related to conjugated linoleic acid (CLA) found in pomegranate oil. Punicic oil in pomegranate seed oil, has been called a"super CLA", whose effect is even more potent than ordinary CLA, generally found in animal meats.

Did you also know that Pomegranate Seed Oil is an excellent skin moisturizer?

Without moisture, our body's fine lines and wrinkles are more abundant and pronounced, our skin looks tight and our complexion lacks luster.

Pomegranate Seed Oil possesses natural estrogenic properties that can help revitalize your skin, smooth fine wrinkles, and help you look and feel more youthful.

Pomegranate Seed Oil Capsules contain pure seed oil that when applied topically imparts a youthful, radiant glow.

Pomegranate Seed Oil offers majoranti-aging benefits, protects against free radicals and damaging environmental effects, and most importantly, leaves your skin feeling baby bottom soft. Skin stays healthy, toned, hydrated and radiates a youthful glow.

Young pHorever CLA(TM) Pomegranate seed oil, rich in antioxidants, is also a natural anti-inflammatory that can help provide quick relief from minor skin irritations.

Pomegranates and the CLA oil from pomegranate seed oil has received considerable attention of late, for their potential medicinal properties.

I will be posting many studies that have been published about pomegranates and pomegranate seed oil at:

http://www.articlesofhealth.blogspot.com/

On the heels of the discovery by Israeli researchers that pomegranate oil has antioxidant properties, another Israeli team has found thatthe fruit could have important implications for breast cancer treatment and estrogen replacement therapy.

The Technion-Israel Institute of Technology research team presented two studies at an international conference last June indicating that pomegranate seed oil triggers apoptosis -- a self-destruct mechanismin breast cancerous cells.

Furthermore, pomegranate oil can be toxic to mostestrogen-dependent breast cancerous cells, while leaving normal breast cells largely unaffected.

Estrogen is a hormone often prescribed to protect postmenopausal women against heart disease and osteoporosis.

In the first study, laboratory-grown breast cancerous cells were treated for three days with pomegranate seed oil. The researchers observed apoptosis in 37 to 56 percent of the cancerous cells, depending upon the dose of oil applied.

In the second study, both normal and cancerous breast cells were exposed to pomegranate juice and pomegranate peel extracts, which contain polyphenols (powerful antioxidants).

The vast majority of the normal cells remained unaffected by the two pomegranate derivatives.

But more than 75 percent of the estrogen-dependent cancerous cells, and approximately half of thenon-estrogen dependent cancerous cells were transformed by exposure to these same pomegranate products.

"Pomegranates are unique in that the hormonal combinations inherent in the fruit seem to behelpful both for the prevention and treatmentof breast cancer," explains Dr. Ephraim Lansky,who headed the studies. "Pomegranates seem to replace needed estrogen often prescribed to protect postmenopausal women against heart disease and osteoporosis, while selectively destroying estrogen-dependent cancer cells."

Dr. Martin Goldman, a New York-based board certified internist and life medicine specialist, notes, "This is apparently a safe substance that could be helpful to many people, especially women at high-risk for developing breast cancer."

Dr. Lajos Pusztai, an assistant professor whostudies breast cancer at the M.D. Anderson Cancer Center in Houston, Texas, says Dr.Lansky's study "provides a potential new avenue to develop anti-cancerous drugs froma natural compound."

Technion researchers have tested other health benefits of the pomegranate. In 1999, they were among the first to publish research showingthe antioxidant potency of pomegranates.

A later Technion study found that the daily consumption of pomegranate oil dramatically lowered oxidation of LDL cholesterol, leadingto the elimination of plaques in coronaryarteries.

Based on these studies, Dr. Robert O. Young is launching three new products intended to be antioxidant and anti-aging.

Dr. Young's products are scheduled to reach theU.S. and International markets this summer.

Dr. Young's products include an encapsulated mixtureof pomegranate oil and juice extract, seeds and peel derivatives, avocado powder, cucumber powder, gogi powder, mangosteen powder, noni powder, acaipowder, grapefruit powder, lemon powder, lime powder, and many other alkalizing, antioxidant and anti-aging ingredients (without all the acidic sugar) in a synergistic encapsulated formula called, pHruits(TM).

This product will also be available in a powderform to mix with alkaline ionized water.

It will be sold as pHruits(TM) under the labelof Young pHorever(TM), by pH Miracle.

For more information about Dr. Robert O. Young'spomegranate products, go to:

http://www.phmiracleliving.com/ orhttp://www.articlesofhealth.blogspot.com/

If you would like to purchase our pHorever Young CLA(TM)Pomegranate Seed Oil just give us a call at:

760-751-8321 or go to: http://www.phmiracleliving.com/

The price for the Young pHorever CLA(TM)90 - 1000 mg. veggie caps is $51.00per bottle.
Take 1 capsule 3 times a day.One bottle should last 30 days.

Look for Young pHorever pHruits(TM)coming out the middle of July or around the first of August.

It will be the world's first alkalizing combinationof powerful antioxidant and anti-aging pHruits(TM)ever developed and available in 500mg. capsules orone pound powder of Young pHorever pHruits(TM)to be mixed in alkaline ionized water.

Young pHorever pHruits(TM) contains no added sugars and has a low sugar index unlike most exotic fruit drinks or fruit suppelements on the market today.

The price for Young pHorever pHruits(TM) 90 - 500 mg.veggie caps is $51.00. Take 1 capsule 3 timesa day. One bottle will last 30 days.

The price for one pound of powdered Young pHorever pHruits(TM)is $89.00. Put 1 to 3 scoops of Young pHorever pHruits(TM) powder in one liter of alkaline ionized water at least 3 times daily. One bottle will last at least 45 days.

You can NOW pre-order Young pHorever pHruits(TM) for delivery in mid-July by calling
760-751-8321.

You can order NOW for delivery NOW Young pHorever CLA by calling 760-751-8321.

For more information on pH Miracle Living go to:

http://www.phmiracleliving.com/

Write us at:

phruits@aol.com or pHmiraclesecrets@aol.com

Copyright © 2007 by Robert O. Young, Ph.D., D.Sc.

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